2025
Rare variants and survival of patients with idiopathic pulmonary fibrosis: analysis of a multicentre, observational cohort study with independent validation
Aitana Alonso-González, David Jáspez, José M. Lorenzo-Salazar, Shwu-Fan Ma, Emma Strickland, Josyf Mychaleckyj, John S. Kim, Yong Huang, Ayodeji Adegunsoye, Justin M. Oldham, Iain Stewart, Philip L. Molyneaux, Toby M. Maher, Louise V. Wain, Richard J. Allen, R. Gisli Jenkins, Jonathan A. Kropski, Brian Yaspan, Timothy S. Blackwell, David Zhang, Christine Kim Garcia, Fernando J. Martinez, Imre Noth, Carlos Flores
Lancet Respir Med, vol. 13, no. 6, pp. 495–504
View Publication2025
Durotaxis is a driver and potential therapeutic target in lung fibrosis and metastatic pancreatic cancer
Taslim A. Al-Hilal, Maria-Anna Chrysovergi, Paula E. Grasberger, Fei Liu, Vera Auernheimer, Yan Zhou, Zebin Xiao, Mark Anthony Leon-Duque, Alba Santos, Tamanna Islam, Matteo Ligorio, Delphine Sicard, Clemens K. Probst, Vladimir Vrbanac, Tejaswini S. Reddi, Ludovic Vincent, Cassandra Happe, Edward Chaum, Charles R. Yates, Kaveh Daneshvar, Allan C. Mullen, David Ting, Eric S. White, Raghu Kalluri, Christina M. Woo, Ellen Puré, Wolfgang H. Goldmann, Jose Luis Alonso, Andrew M. Tager, Adam J. Engler, Daniel J. Tschumperlin, David Lagares
Nat Cell Biol, vol. 27, no. 9, pp. 1543–1554
View Publication2025
Morphometry and mechanical instability at the onset of epithelial bladder cancer
Franziska L. Lampart, Roman Vetter, Kevin A. Yamauchi, Yifan Wang, Steve Runser, Nico Strohmeyer, Florian Meer, Marie-Didiée Hussherr, Gieri Camenisch, Hans-Helge Seifert, Cyrill A. Rentsch, Clémentine Le Magnen, Daniel J. Müller, Lukas Bubendorf, Dagmar Iber
Nat. Phys., vol. 21, no. 2, pp. 279–288
View Publication2025
Idiopathic Pulmonary Fibrosis, Today and Tomorrow: Certainties and New Therapeutic Horizons
Giacomo Giulianelli, Elisabetta Cocconcelli, Gioele FiorentĂą, Nicol Bernardinello, Manuel G. Cosio, Elisabetta Balestro
Pulm Ther, vol. 11, no. 2, pp. 195–234
View Publication2023
Graphdiyne Oxide-Mediated Photodynamic Therapy Boosts Enhancive T-Cell Immune Responses by Increasing Cellular Stiffness
Lejia Zhang, Jialing Hu, Xiping Zeng, Shoulei Wang, Huijuan Song, Jianling Yang, Xiaoyuan Cao, Zhenhai Chen, Yuebin Li, Lei Chen
Int J Nanomedicine, vol. 18, pp. 797–812
View Publication2022
Dedifferentiation-mediated stem cell niche maintenance in early-stage ductal carcinoma in situ progression: insights from a multiscale modeling study
Joseph D. Butner, Prashant Dogra, Caroline Chung, Javier Ruiz-RamĂrez, Sara Nizzero, Marija Plodinec, Xiaoxian Li, Ping-Ying Pan, Shu-Hsia Chen, Vittorio Cristini, Bulent Ozpolat, George A. Calin, Zhihui Wang
Cell Death Dis, vol. 13, no. 5, p. 485
View Publication2022
Discriminating bladder cancer cells through rheological mechanomarkers at cell and spheroid levels
K. Gnanachandran, S. Kędracka-Krok, J. Pabijan, and M. Lekka
J Biomech, vol. 144, p. 111346
View Publication2021
Immune Modulatory Properties of Collagen in Cancer
A. M. A. Rømer, P. B. Thorseth, D. H. Madsen
Front Immunol, vol. 12, p. 791453
View Publication2021
Tumor stiffening reversion through collagen crosslinking inhibition improves T cell migration and anti-PD-1 treatment
Alba Nicolas-Boluda, Javier Vaquero, Lene Vimeux, Thomas Guilbert, Sarah Barrin, Chahrazade Kantari-Mimoun, Matteo Ponzo, Gilles Renault, Piotr Deptula, Katarzyna Pogoda, Robert Bucki, Ilaria Cascone, José Courty, Laura Fouassier, Florence Gazeau, Emmanuel Donnadieu
eLife, vol. 10, p. e58688
View Publication2021
A Mathematical Model to Estimate Chemotherapy Concentration at the Tumor-Site and Predict Therapy Response in Colorectal Cancer Patients with Liver Metastases
Daniel A. Anaya, Prashant Dogra, Zhihui Wang, Mintallah Haider, Jasmina Ehab, Daniel K. Jeong, Masoumeh Ghayouri, Gregory Y. Lauwers, Kerry Thomas, Richard Kim, Joseph D. Butner, Sara Nizzero, Javier Ruiz RamĂrez, Marija Plodinec, Richard L. Sidman, Webster K. Cavenee, Renata Pasqualini, Wadih Arap, Jason B. Fleming, Vittorio Cristini
Cancers, vol. 13, no. 3, p. 444
View Publication2021
Thymus Extracellular Matrix-Derived Scaffolds Support Graft-Resident Thymopoiesis and Long-Term In Vitro Culture of Adult Thymic Epithelial Cells
M. A. Asnaghi, T. Barthlott, F. Gullotta, V. Strusi, A. Amovilli, K. Hafen, G. Srivastava, P. Oertle, R. Toni, D. Wendt, G. A. Holländer, I. Martin
Adv. Funct. Mater., vol. 31, no. 20, p. 2010747
View Publication2021
A mathematical model for the quantification of a patient's sensitivity to checkpoint inhibitors and long-term tumour burden
Joseph D. Butner, Prashant Dogra, Caroline Chung, Renata Pasqualini, Wadih Arap, John Lowengrub, Vittorio Cristini, Zhihui Wang
Nat Biomed Eng, vol. 5, no. 4, pp. 297–308
View Publication2020
GPER Activation Inhibits Cancer Cell Mechanotransduction and Basement Membrane Invasion via RhoA
Rice, A.; Cortes, E.; Lachowski, D.; Oertle, P.; Matellan, C.; Thorpe, S.D.; Ghose, R.; Wang, H.; Lee, D.A.; Plodinec, M.; et al.
Cancers, vol. 12, no. 2, p. 289
View Publication2020
Top 10 Challenges in Cancer Immunotherapy
P. S. Hegde and D. S. Chen
Immunity, vol. 52, no. 1, pp. 17–35
View Publication2020
Radiation therapy and the innate immune response: Clinical implications for immunotherapy approaches
V. Gómez, S. C. Formenti, J. L. Piris-Giménez
Br J Clin Pharmacol, vol. 86, no. 9, pp. 1726–1735
View Publication2020
Optimizing Radiation Therapy to Boost Systemic Immune Responses in Breast Cancer: A Critical Review for Breast Radiation Oncologists
Alice Y. Ho, Jean L. Wright, Rachel C. Blitzblau, Robert W. Mutter, Dan G. Duda, Larry Norton, Aditya Bardia, Laura Spring, Steven J. Isakoff, Jonathan H. Chen, Clemens Grassberger, Jennifer R. Bellon, Sushil Beriwal, Atif J. Khan, Corey Speers, Samantha A. Dunn, Alastair Thompson, Cesar A. Santa-Maria, Ian E. Krop, Elizabeth Mittendorf, Tari A. King, Gaorav P. Gupta
International Journal of Radiation Oncology*Biology*Physics, vol. 108, no. 1, pp. 227–241
View Publication2020
Real-World Outcomes for Patients treated With Immune Checkpoint Inhibitors in the Veterans Affairs System
Jerry La, Doreen Cheng, Kelly M. Beauchemin, Michael T. Brophy, Nhan V. Do, Mary Hanchate, Yinong Young-Xu, Nancy R. Lachance, Mark Nickleach, Jeremy Force, David M. Jackman
JCO Clinical Cancer Informatics, no. 4, pp. 918–928
View Publication2020
Pancreatic cancer stroma: an update on therapeutic targeting strategies
A. N. Hosein, R. A. Brekken, A. Maitra
Nat Rev Gastroenterol Hepatol, vol. 17, no. 8, pp. 487–505
View Publication2020
Low-dose radiation treatment enhances systemic antitumor immune responses by overcoming the inhibitory stroma
Hampartsoum B. Barsoumian, Ahmed I. Younes, Joe E. Saada, Maria Sebastia Corvera, Duygu Sezen, Fatemeh Masrorpour, Ailing Huang, Thomas Paul Riad, James W. Welsh, David S. Hong, Roshal Patel, Adi Diab, Roza Nurieva, Natalie I. Cos, Hari Menon, Taylor R. Cushman, Isabella C. Glitza, Stephen G. Chun, Quynh-Nhu Nguyen, Maria Angelica Cortez
J Immunother Cancer, vol. 8, no. 2, p. e000537
View Publication2020
Pancreatic ductal adenocarcinoma progression is restrained by stromal matrix
Honglin Jiang, Robert J. Torphy, Katja Steiger, Henry Hongo, Alexa J. Ritchie, Mark Kriegsmann, David Horst, Sarah E. Umetsu, Nancy M. Joseph, Kimberly McGregor, Michael J. Pishvaian, Edik M. Blais, Brian Lu, Mingyu Li, Michael Hollingsworth, Connor Stashko, Keith Volmar, Jen Jen Yeh, Valerie M. Weaver, Zhen J. Wang, Margaret A. Tempero, Wilko Weichert, Eric A. Collisson
J Clin Invest, vol. 130, no. 9, pp. 4704–4709
View Publication2020
Fibrosis and cancer: A strained relationship
B. Piersma, S. Hayward, R. Weaver
Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, vol. 1873, no. 2, p. 188356
View Publication2019
Phase II Trial of Ipilimumab with Stereotactic Radiation Therapy for Metastatic Disease: Outcomes, Toxicities, and Low-Dose Radiation–Related Abscopal Responses
James W. Welsh, Chad Tang, Patricia de Groot, Aung Naing, Kenneth R. Hess, John V. Heymach, Vassiliki A. Papadimitrakopoulou, Taylor R. Cushman, Vivek Subbiah, Joe Y. Chang, George R. Simon, Rishab Ramapriyan, Hampartsoum B. Barsoumian, Hari Menon, Maria Angelica Cortez, Erminia Massarelli, Quynh Nguyen, Padmanee Sharma, James P. Allison, Adi Diab, Vivek Verma, Uma Raju, Sherif G. Shaaban, Ramona Dadu, Maria E. Cabanillas, Kelvin Wang, Clark Anderson, Daniel R. Gomez, Stephen Hahn, Ritsuko Komaki, David S. Hong
Cancer Immunol Res, vol. 7, no. 12, pp. 1903–1909
View Publication2019
Unraveling the Mechanobiology of the Immune System
J.-K. Kim, A. Mitra, A. N. Alfaro, and S. S. Suh
Adv. Healthcare Mater., p. 1801332
View Publication2019
Mechanobiology of Macrophages: How Physical Factors Coregulate Macrophage Plasticity and Phagocytosis
N. Jain, K. H. Vogel
Annual Review of Biomedical Engineering, vol. 20, p. 33
View Publication2019
The Extracellular Matrix Modulates the Metastatic Journey
F. Kai, A. P. Drain, and V. M. Weaver
Developmental Cell, vol. 49, no. 3, pp. 332–346
View Publication2019
Molecular Mechanisms of Breast Cancer Metastasis to the Lung: Clinical and Experimental Perspectives
B. Medeiros and A. L. Allan
Int J Mol Sci, vol. 20, no. 9, p. 2272
View Publication2018
Structural centrosome aberrations promote non-cell-autonomous invasiveness
Olivier Ganier, Daniela Schnerch, Patrick Oertle, Roderick Y. H. Lim, Erich A. Nigg, Danijela Matic Vignjevic
The EMBO Journal, vol. 37, no. 9, p. e98576
View Publication2018
HtrA1 Mediated Intracellular Effects on Tubulin Using a Polarized RPE Disease Model
Melo E, Oertle P, Trepp C, Meistermann H, Burgoyne T, Sborgi L, Cabrera AC, Chen CY, Hoflack JC, Kam-Thong T, Schmucki R, Badi L, Flint N, Ghiani ZE, Delobel F, Stucki C, Gromo G, Einhaus A, Hornsperger B, Golling S, Siebourg-Polster J, Gerber F, Bohrmann B, Futter C, Dunkley T, Hiller S, Schilling O, Enzmann V, Fauser S, Plodinec M, Iacone R
EBioMedicine, vol. 27, pp. 258–274
View Publication2018
A three-dimensional in vitro dynamic micro-tissue model of cardiac scar formation
Paola Occhetta, Giuseppe Isu, Marta Lemme, Chiara Conficconi, Philipp Oertle, Christian Räz, Roberta Visone, Giulia Cerino, Marija Plodinec, Marco Rasponi, Anna Marsano
Integrative Biology, vol. 10, no. 3, pp. 174–183
View Publication2018
Combining Immunotherapy and Radiotherapy for Cancer Treatment: Current Challenges and Future Directions
Yifan Wang, Wei Deng, Ning Li, Chad S. Neri, Amol J. Sharma, Weiguo Jiang, Steven H. Lin
Front. Pharmacol., vol. 9, p. 185
View Publication2018
Length Scale Matters: Real-Time Elastography versus Nanomechanical Profiling by Atomic Force Microscopy for the Diagnosis of Breast Lesions
Rosanna Zanetti-Dällenbach, Marija Plodinec, Philipp Oertle, Katharina Redling, Ellen C. Obermann, Roderick Y. H. Lim, Cora-Ann Schoenenberger
BioMed Research International, vol. 2018, pp. 1–12
View Publication2018
Biomaterial surface energy-driven ligand assembly strongly regulates stem cell mechanosensitivity and fate on very soft substrates
Troii Razafiarison, Tomaz Silvan, Unai Mendable, Nicolas Boerboom, Marcy Zenobi-Wong, Katharina Maniura-Weber, Marija Plodinec, Rowena L. Schoenenberger, Jess G. Snedeker
Proceedings of the National Academy of Sciences, p. 201704543
View Publication2017
Surface plasmon resonance methodology for monitoring polymerization kinetics and morphology changes of brushes—evaluated with poly(N-isopropylacrylamide)
Gustav Emilsson, Rafael L. Schoch, Philipp Oertle, Kunli Xiong, Roderick Y.H. Lim, Andreas B. Dahlin
Applied Surface Science, vol. 396, pp. 384–392
View Publication2017
Diabetes-related changes in the protein composition and the biomechanical properties of human retinal vascular basement membranes
Halfter W, Moes S, Asgeirsson DO, Halfter K, Oertle P, Melo Herraiz E, et al.
PLOS ONE, vol. 12, no. 12, p. e0189857
View Publication2017
Cancer-associated fibroblasts induce metalloprotease-independent cancer cell invasion of the basement membrane
Alexandros Glentis, Philipp Oertle, Pascale Mariani, Aleksandra Chikina, Fatima El Marjou, Youmna Attieh, Francois Zaccarini, Marick Lae, Damarys Loew, Florent Dingli, Philemon Sirven, Marie Schoumacher, Basile G. Gurchenkov, Marija Plodinec, Danijela Matic Vignjevic
Nature Communications, vol. 8, no. 1
View Publication2016
Clusters of circulating tumor cells traverse capillary-sized vessels
Sam H. Au, Brian D. Storey, John C. Moore, Qin Tang, Yeng-Long Chen, Sarah Javaid, A. Fatih Sarioglu, Ryan Sullivan, Marissa W. Madden, Ryan O'Keefe, Daniel A. Haber, Shyamala Maheswaran, David M. Langenau, Shannon L. Stott, Mehmet Toner
Proc Natl Acad Sci USA, vol. 113, no. 18, pp. 4947–4952
View Publication2016
Superior Rim Stability of the Lens Capsule Following Manual Over Femtosecond Laser Capsulotomy
Magaly Reyes Lua, Philipp Oertle, Leon Camenzind, Alexandra Goz, Carsten H. Meyer, Katarzyna Konieczka, Marko Loparic, Willi Halfter, Paul Bernhard Henrich
Investigative Ophthalmology & Visual Science, vol. 57, no. 6, p. 2839
View Publication2016
Recent advances in the biology of human circulating tumour cells and metastasis
S. Gkountela and C. A. Klein
ESMO Open, vol. 1, no. 4, p. e000078
View Publication2016
The Nanomechanical Signature of Tissues in Health and Disease
D. O. Asgeirsson, M. Plodinec, C.-A. Schoenenberger
Nanoscience and Nanotechnology for Human Health, pp. 209–240
View Publication2015
Mammary stem cells: methods and protocols
M. del M. Vivanco (Ed.)
Humana Press, Methods in molecular biology, no. 1293
View Publication2015
New concepts in basement membrane biology
W. Halfter, S. Candiello, H. R. Hu, P. Zhang, E. Schreiber, P. S. Balasubramani
FEBS Journal, vol. 282, no. 23, pp. 4466–4479
View Publication2015
The impact of tumor stroma on drug response in breast cancer
J. Dittmer and B. Leyh
Seminars in Cancer Biology, vol. 31, pp. 3–15
View Publication2015
Nonmulberry Silk Fibroin Scaffold Shows Superior Osteoconductivity Than Mulberry Silk Fibroin in Calvarial Bone Regeneration
Sahu, N., Baligar, P., Midha, S., Kundu, B., Bhattacharjee, M., Mukherjee, S., Mukherjee, S., Maushart, F., Das, S., Loparic, M., Kundu, S.C., Ghosh, S. and Mukhopadhyay, A.
Advanced Healthcare Materials, vol. 4, no. 11, pp. 1709–1721
View Publication2015
The future of immune checkpoint therapy
P. Sharma and J. P. Allison
Science, vol. 348, no. 6230, pp. 56–61
View Publication2014
Transport properties of pancreatic cancer describe gemcitabine delivery and response
Eugene J. Koay, Mark J. Truty, Vittorio Cristini, Ryan M. Thomas, Rong Chen, Deyali Chatterjee, Ya'an Kang, Priya R. Bhosale, Eric P. Tamm, Christopher H. Crane, Milind Javle, Matthew H. Katz, Vijaya N. Gottumukkala, Marc A. Rozner, Haifa Shen, Jeffery E. Lee, Huamin Wang, Yuling Chen, William Plunkett, James L. Abbruzzese, Robert A. Wolff, Gauri R. Varadhachary, Mauro Ferrari, Jason B. Fleming
J. Clin. Invest., vol. 124, no. 4, pp. 1525–1536
View Publication2013
Diabetes-induced morphological, biomechanical, and compositional changes in ocular basement membranes
Margaret To, Alexandra Goz, Leon Camenzind, Philipp Oertle, Joseph Candiello, Mara Sullivan, Paul Bernhard Henrich, Marko Loparic, Farhad Safi, Andrew Eller, Willi Halfter
Experimental Eye Research, vol. 116, pp. 298–307
View Publication2013
The Bi-Functional Organization of Human Basement Membranes
Halfter W, Monnier C, MĂĽller D, Oertle P, Uechi G, Balasubramani M, et al.
PLoS ONE, vol. 8, no. 7, p. e67660
View Publication2013
Material Properties of the Internal Limiting Membrane and Their Significance in Chromovitrectomy
Paul B. Henrich, Christophe A. Monnier, Marko Loparic, Philippe C. Cattin
Ophthalmologica, vol. 230, no. s2, pp. 11–20
View Publication2013
The role of 3D structure and protein conformation on the innate and adaptive immune responses to silk-based biomaterials
Maumita Bhattacharjee, Elke Schultz-Thater, Emanuele Trella, Sylvie Miot, Sanskrita Das, Marko Loparic, Alok R. Ray, Ivan Martin, Giulio C. Spagnoli, Sourabh Ghosh
Biomaterials, vol. 34, no. 33, pp. 8161–8171
View Publication2013
Mechanical properties of biological specimens explored by atomic force microscopy
S. Kasas, G. Longo, G. Dietler
J. Phys. D: Appl. Phys., vol. 46, no. 13, p. 133001
View Publication2012
Nanoscale Topographic and Biomechanical Studies of the Human Internal Limiting Membrane
Paul B. Henrich, Christophe A. Monnier, Willi Halfter, Christos Haritoglou, Rupert W. Strauss, Roderick Y. H. Lim, Marko Loparic
Investigative Opthalmology & Visual Science, vol. 53, no. 6, p. 2561
View Publication2012
Oriented lamellar silk fibrous scaffolds to drive cartilage matrix orientation: Towards annulus fibrosus tissue engineering
Maumita Bhattacharjee, Sylvie Miot, Agata Gorecka, Kunal Singha, Marko Loparic, Sally Dickinson, Anup Das, Neel Sarovar Bhavesh, Alok R. Ray, Ivan Martin, Sourabh Ghosh
Acta Biomaterialia, vol. 8, no. 9, pp. 3313–3325
View Publication2012
Sliding motion modulates stiffness and friction coefficient at the surface of tissue engineered cartilage
Grad S, Loparic M, Peter R, Stolz M, Aebi U, Alini M
Osteoarthritis and Cartilage, vol. 20, no. 4, pp. 288–295
View Publication2012
The nanomechanical signature of breast cancer
Marija Plodinec, Marko Loparic, Cora-Ann Schoenenberger, Roderick P. Lim, Janos Vörös, Christoph Gerber, Ueli Aebi
Nat Nano, vol. 7, no. 11, pp. 757–765
View Publication2011
The nanomechanical properties of rat fibroblasts are modulated by interfering with the vimentin intermediate filament system
Marija Plodinec, Marko Loparic, Reinhard Suetterlin, Harald Herrmann, Ueli Aebi, Cora-Ann Schoenenberger
Journal of Structural Biology, vol. 174, no. 3, pp. 476–484
View Publication2010
Articular cartilage repair by genetically modified bone marrow aspirate in sheep
Ivkovic, A., Pascher, A., Hudetz, D. et al.
Gene Therapy, vol. 17, no. 6, pp. 779–789
View Publication2010
Atomic Force Microscopy for Biological Imaging and Mechanical Testing across Length Scales
Marija Plodinec, Marko Loparic, Ueli Aebi
Cold Spring Harbor Protocols, vol. 2010, no. 10, p. pdb.top86
View Publication2010
Spatial organization acts on cell signaling: how physical force contributes to the development of cancer
M. Plodinec and C.-A. Schoenenberger
Breast Cancer Research, vol. 12, no. 4
View Publication2010
Micro- and Nanomechanical Analysis of Articular Cartilage by Indentation-Type Atomic Force Microscopy: Validation with a Gel-Microfiber Composite
Loparic M, Wirz D, Daniels AU, Raiteri R, Vanlandingham MR, Guex G, Martin I, Aebi U, Stolz M
Biophysical Journal, vol. 98, no. 11, pp. 2731–2740
View Publication2010
Glioma cells display complex cell surface topographies that resist the actions of cytolytic effector lymphocytes
Neil Hoa, Lisheng Ge, Yurii Kuznetsov, Alex McPherson, Andrew N. Cornforth, Jimmy T. H. Pham, Michael P. Myers, Nabil Ahmed, Vita S. Salsman, Lawrence S. Lamb Jr, Joscelyn E. Bowersock, Yuanjie Hu, Yi-Hong Zhou, Martin R. Jadus
J Immunol, vol. 185, no. 8, pp. 4793–4803
View Publication2008
AFM-based analysis of human metastatic cancer cells
S. E. Cross, Y.-S. Jin, J. Tondre, R. Wong, J. Rao, and J. K. Gimzewski
Nanotechnology, vol. 19, no. 38, p. 384003
View Publication2003
Interstitial Stress and Fluid Pressure Within a Growing Tumor
M. Sarntinoranont, F. Rooney, and M. Ferrari
Annals of Biomedical Engineering, vol. 31, no. 3, pp. 327–335
View PublicationOur journey began with a breakthrough discovery published in Nature Nanotechnology in 2012: “The nanomechanical signature of breast cancer” by Marija Plodinec and colleagues.
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